First published: 10th October 2023
Cumulus Neuroscience presented data from a feasibility pilot study at the European College of Neuropsychopharmacology (ECNP) Annual Meeting in Barcelona, Spain on October 10th. Using the proprietary Cumulus Neuroassessment Platform to gather data via repeated at-home sampling, the study was conducted on behalf of a biopharma study sponsor.
Cumulus presented a poster titled "A low-burden visual evoked potential measurement of neuroplasticity: real-world feasibility and data quality from an at-home pilot study", which demonstrated that translational markers of long-term potentiation (LTP) can be collected at home with minimal support using a dry electrode, 16-channel, EEG (electroencephalogram) headset. LTP is a synaptic plasticity phenomenon related to learning and memory which is used widely in animal studies. However, direct measurement of LTP is highly invasive and, therefore, cannot be performed in human studies.
“The ability to measure neuroplasticity is relevant to many disease states in neuropsychiatry, often reflecting the capacity of a patient to improve. In contrast to expensive and time-consuming lab-based surrogates, such as MRI and TMS, we have demonstrated that we can get a more direct measure of LTP in a way that is convenient for patients and clinical teams."
Brian Murphy, Ph.D.
CSO, Cumulus Neuroscience
“The ability to measure neuroplasticity is relevant to many disease states in neuropsychiatry, often reflecting the capacity of a patient to improve. In contrast to expensive and time-consuming lab-based surrogates, such as MRI and TMS, we have demonstrated that we can get a more direct measure of LTP in a way that is convenient for patients and clinical teams,” said Brian Murphy, PhD, Founder and Chief Scientific Officer of Cumulus. “We are excited to share data from this important pilot study confirming the feasibility of measuring neuroplasticity in human subjects in a real-world setting using our dry sensor, FDA-cleared 16-channel EEG headset.”
This pilot study offers proof of concept that at-home data collection leveraging wearable technologies has the potential to enable screening, staging, and monitoring of brain function longitudinally in clinical studies.
Cumulus is also the co-author of a second poster that was presented at ECNP in collaboration with the biopharma study sponsor titled, “A low-burden non-invasive measurement of neuroplasticity: feasibility for use in early drug development trials".